VARUNÉ Bio is an R&D company focused on ingredients and formulations for cosmetic and medicinal applications. Skincare is our first commercial focus. Our proposed programmes connect molecular science with a defined formulation problem.
Discuss a research programmeMolecular identity, water and interfaces influence how a formulation behaves. We ask how those changes affect useful function, from the bulk mixture to the film formed during use.
Our scientific approachConceptual molecular–interface illustration.
We are defining ingredient research around pigment production and transfer, local availability and formulation behaviour. Tinted under-eye skincare is the first proposed application, with temporary optical correction evaluated separately from any biological contribution.
Explore skin pigmentation
Immediate optical correction and repeated-use bare-skin changes are separate questions.
A high-priority programme asks whether a characterised polar-associated polymer can alter water release from an ambient film. The useful comparison is with established formulation materials, with molecular identity kept accountable.
Explore polar materialsA cell-free material must retain active enzyme while allowing reactants to reach it and photons to leave. Our proposed first milestone is an inert-surface demonstrator that can distinguish chemical output from transport and optical effects.
Explore biochemical lightPublished reference NanoLuc-catalysed furimazine oxidation produces furimamide and light.* marks an excited state; intermediates and CO2 omitted. Reference chemistry, not a selected VARUNÉ candidate.
Hydrated material on an inert surface. Symbols, dimensions and transport paths are illustrative.
Explore what controls the output
Substrate presentation, oxygen supply and diffusion through the material influence access to the active site.
Confinement can protect a protein while restricting reactant access. Retention and catalytic activity require separate evidence.
Absorption, scattering and the collection geometry affect detected output. A brighter photograph does not establish a faster reaction.
No excitation lamp is needed for this reaction. The energy comes from the oxidation of a luciferin substrate.
Direct fluorescence requires absorbed light. Here, chemistry supplies the excitation energy. A fluorescent acceptor can also receive energy from a biochemical donor through BRET; no external excitation lamp is then required. See the protein-pair study.
Can a defined material retain an active catalyst while allowing reactants in and light out? The proposed first milestone is an inert-surface laboratory demonstrator. No emitting product or company result is shown.
Schematic only. Motion indicates direction, not measured rates, brightness or duration.
Explore the evidence, molecular rationale and formulation questions behind each programme. Request a working paper for a fuller research discussion.
We welcome non-confidential discussion with academic researchers and commercial R&D teams. Start with the application, the scientific question and the expertise needed to investigate it.
Discuss a research programmeVarun Sharma on the evidence, formulation knowledge and technology transfer needed to turn pharmaceutical capacity into capability.
Read the published articleFounder commentary. This is separate from VARUNÉ Bio’s research proposals and experimental findings.
Varun Sharma founded VARUNÉ Bio to connect useful scientific questions with the people equipped to investigate them. His role is to shape the company’s direction and build the relationships needed for focused research.
Meet Varun Sharma